A 50-year-old woman who visited hospital seven times with slurred speech and extreme tiredness, only to be discharged with a diagnosis of being drunk, had a rare condition that gave her the appearance of being intoxicated.
This happened even after saying she had not been drinking. Called auto-brewery syndrome, the condition sees fungi in the gut create alcohol through fermentation.
Experts describe auto-brewery syndrome as “an extremely rare condition in which bacteria and fungus in the gastrointestinal tract turn the carbohydrates in everyday food into ethanol.”
Researchers say awareness of this syndrome – which has social, legal, and medical consequences – is essential for proper diagnosis and management.
Over two years, the woman visited the emergency department complaining of extreme daytime sleepiness and slurred speech.
She had been on several antibiotic courses for recurrent urinary tract infections, alongside a proton pump inhibitor to reduce the amount of acid in her stomach.
Despite not drinking alcohol, she also had elevated blood alcohol levels and alcohol on her breath.
After each hospital visit the woman was discharged with the diagnosis of alcohol intoxication, despite her reports of no alcohol intake, which her family confirmed.
The patient needed up to two weeks off work after each episode and during this time she ate very little.
Her symptoms would improve after one to two weeks but would return every one to two months.
On the third visit, the mother was even certificated under the Mental Health Act, as the doctor had concerns about self-neglect when she discharged herself before psychiatric assessment.
However, on her seventh visit, the emergency doctor considered a diagnosis of auto-brewery syndrome, and after being prescribed some medication, she was referred to a specialist.
A dietitian suggested a low-carbohydrate diet, and after completing a one-month course of antifungal medication and the diet, the woman’s symptoms went away and remained absent for four months.
The woman slowly started to eat carbohydrates again, but one month after doing this, she had a recurrence of slurred speech and drowsiness, which led to a fall.
She was advised to restart the low-carbohydrate diet again, and her symptoms resolved.
Writing in the Canadian Medical Association Journal, Dr. Rahel Zewude, University of Toronto, and her co-authors, said: “Auto-brewery syndrome carries substantial social, legal, and medical consequences for patients and their loved ones.
“Our patient had several (emergency department) visits, was assessed by internists and psychiatrists, and was certified under the Mental Health Act before receiving a diagnosis of the auto-brewery syndrome, reinforcing how awareness of this syndrome is essential for clinical diagnosis and management.” (dpa/NAN)
